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Global oligonucleotide synthesis market worth $4.2bn in 2025

Industrial Market Research

The global Oligonucleotide Synthesis Market was valued at US$ 1,650.0 Mn in 2016 and is estimated to reach US$ 4,189.9 Mn by 2025 at a CAGR of 11.2% from 2017 to 2025.

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Oligonucleotide synthesis is the process of synthetically producing nucleic acid biomolecules with definite sequences. The technique is an inexpensive and provides rapid access of desired sequence of custom oligonucleotides.

The process is widely used in research and development activities across the life sciences industry including, drug manufacture, medical diagnosis, and several applications in the food and agriculture industry.

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The technological advances in synthetic chemistry, and growing application of oligonucleotides in therapeutics and diagnostics applications is expected to drive the growth of oligonucleotide synthesis market over the forecast period. The technological advances in synthesis of oligonucleotides provides longer with better sequence and pure oligonucleotides that can be used in a number of molecular biology applications.

Various pharmaceutical and biotechnology companies are continuously working on developing newer and advanced methods in synthetic chemistry. For instance, Integrated DNA Technologies, leader of synthesized oligonucleotides has developed various pioneered methods to synthesize oligonucleotides of extreme lengths.

The company has developed oligonucleotides up to 200 base length which is used with mass spectrometry for the manufacture of mini-genes.

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The global oligonucleotide synthesis market has been segmented on the basis of product type, application, and end user. The product type segment is further segmented as, reagents & consumables, equipment, and synthesized oligonucleotides.

The synthesized oligonucleotides segment dominated the global Oligonucleotide Synthesis market in 2017. Synthesized oligonucleotides are ready to use oligonucleotides.

Synthesized oligonucleotides are widely used in research, therapeutic and diagnostics applications. These are also available as customized oligos prepared as per need.

There are two types of commercially used synthesized oligonucleotide: DNA oligonucleotides and RNA oligonucleotides. Locked Nucleic acid (LNA) and Bridged Nucleic Acid (BNA) are the other types of synthesized oligonucleotides used in research.

On the basis of application, the global oligonucleotide synthesis market is segmented as research, therapeutics, and diagnostics. The research application segment accounted major share in 2016.

The segment is further segmented as, Polymerase Chain Reaction, Next Generation Sequencing, and Others. The therapeutics segment is expected to grow at high CAGR over the forecast period.

The segment is further categorized into two types, Antisense Oligonucleotides, and Nucleic Acid Aptamers. Rising prevalence of genetic diseases and increasing demand for personalized medicines are expected to boost the growth of segment during the forecast period.

Other than therapeutics and research application of oligonucleotides, they are widely used in various in vitro diagnostic kits and as analyte-specific reagents (ASRs) for laboratory developed tests (LDTs).

By end user, the global Oligonucleotide Synthesis market is segmented as biotechnology & pharmaceutical companies, research institutes, and diagnostic laboratories. Research institutes segment accounted major shares in 2016 by end user in global oligonucleotides synthesis market.

Increasing research applications of oligonucleotides as therapeutic agents for treatment of rare diseases along with rising adoption of next-generation sequencing providing high throughput results are propelling the research institutes segment of the oligonucleotide synthesis market. The biotechnology and pharmaceutical companies segment is expected to register high growth over the forecast period.

Strong and robust R&D pipelines of biopharmaceutical companies in the therapeutics segment involving oligonucleotides drives demand for oligonucleotides in the global market.


The global Oligonucleotide Synthesis market has been segmented into five major regions, namely, North America, Europe, Asia Pacific, Latin America and Middle East & Africa, which are further categorized into various countries under each region. North America dominated the global oligonucleotide synthesis market in 2017 owing to factors such as fast growing life science industry, rising focus on genetics and genomics in the research and diagnostics applications in, and increasing number of pharmaceutical companies focusing on oligonucleotides as therapeutic agents including antisense and RNAi therapeutics are driving demand for oligonucleotides in North America.

Europe was the second largest regional market for oligonucleotide synthesis in 2017, technological advancements for developing new molecules of oligonucleotides for therapeutics.

Asia Pacific is projected to be the most lucrative market for global oligonucleotide synthesis market and is expected to expand at the highest growth rate from 2017 to 2025. Increase in life science R&D spending, especially in China and Japan, and rise in government initiatives, grants, funds, and dedicated research commercial zones are attracting domestic and foreign players to invest and enter the lucrative research sector in Asia Pacific.

Thermo Fisher Scientific dominated the global oligonucleotide synthesis market in 2016. Major factors attributed to its dominance are broad product portfolio and widespread market presence.

Sigma-Aldrich Corporation (a part of Merck KGaA), secured the second market position in 2016. Other players in the global Oligonucleotide Synthesis market includes Integrated DNA Technologies,GE Healthcare, Kaneka Eurogentec S.A., Agilent Technologies, Applied Biosystems, BioAutomation, Eurofins Genomics, GeneDesign, Inc., etc.

and other local and regional players.

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