Baculoviral IAP Repeat Containing Protein 5 (Apoptosis Inhibitor 4 or Apoptosis Inhibitor Survivin or BIRC5) - Baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 also known as Survivin is a protein encoded by the BIRC5 gene. It has dual roles in promoting cell proliferation and preventing apoptosis.
It acts as an important regulator of the localization of this complex directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules.
The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
It counteracts a default induction of apoptosis in G2/M phase. It plays a role in neoplasia.
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- Biomics Biotechnologies Co Ltd
- Bioneer Corp
- Boehringer Ingelheim GmbH
- Immunovaccine Inc
- MimiVax LLC
- Optimum Therapeutics LLC
- Polyplus-Transfection SA
- Stemline Therapeutics Inc
- tella Inc
- Vaxeal Holding SA
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