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Interleukin 1 receptor associated kinase 4 research report available in new report

Medical Market Research

Interleukin 1 Receptor Associated Kinase 4 - Interleukin-1 receptor-associated kinase 4 (IRAK-4) is a protein kinase involved in signaling innate immune responses from Toll-like receptors. Mutations in IRAK-4 result in IRAK4 deficiency and recurrent invasive pneumococcal disease.

It phosphorylates E3 ubiquitin ligases Pellino proteins to promote pellino-mediated polyubiquitination of IRAK1. Ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex.

MAP3K7/TAK1 activates IKKs leading to NF-kappa-B nuclear translocation and activation.

Report Source:…e-review-h1-2018


  • The report provides a snapshot of the global therapeutic landscape for Interleukin 1 Receptor Associated Kinase 4
  • The report reviews Interleukin 1 Receptor Associated Kinase 4 targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Interleukin 1 Receptor Associated Kinase 4 targeted therapeutics and enlists all their major and minor projects

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Reasons To Access

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