Nuclear Factor Erythroid 2 Related Factor 2 (HEBP1 or Nuclear Factor Erythroid Derived 2 Like 2 or NFE2L2) - Nuclear factor (erythroid-derived 2)-like 2 or Nrf2 is a transcription factor encoded by the NFE2L2 gene. It binds to antioxidant response elements in the promoter regions of target genes.
It is important for the coordinated up-regulation of genes in response to oxidative stress.
It is involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
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- Arbor Pharmaceuticals LLC
- Bayer AG
- BioApex sro
- Biogen Inc
- C4X Discovery Holdings PLC
- Catabasis Pharmaceuticals Inc
- Daiichi Sankyo Co Ltd
- Evgen Pharma Plc
- Ixchel Pharma LLC
- Jiangsu Hengrui Medicine Co Ltd
- Mochida Pharmaceutical Co Ltd
- Reata Pharmaceuticals Inc
- Rigel Pharmaceuticals Inc
- vTv Therapeutics Inc
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