Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 220.127.116.11) - Histone deacetylase 6 is an enzyme encoded by the HDAC6 gene. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Histone deacetylases plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. It is involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
It plays a key role in the degradation of misfolded proteins. It acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
Report Source: www.themarketreports.com/report/hi…e-review-h1-2018
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Histone Deacetylase 6 targeted therapeutics and enlists all their major and minor projects
- The report assesses Histone Deacetylase 6 targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Histone Deacetylase 6 targeted therapeutics
Report available at: www.themarketreports.com/report/buy-now/1022573
- AlfaSigma SpA
- Celgene Corp
- Chong Kun Dang Pharmaceutical Corp
- Curis Inc
- HitGen LTD
- Kancera AB
- Karus Therapeutics Ltd
- Medivir AB
- Merck & Co Inc
- Millennium Pharmaceuticals Inc
- OnKure Inc
- Quimatryx SL
- Shuttle Pharmaceuticals LLC
- SK Biopharmaceuticals Co Ltd
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