Type 2 diabetes mellitus (T2DM) is a major metabolic disease and one of the leading causes of death worldwide. The prevalence is on the rise, alongside increases in obesity due to lifestyle changes in the 21st century.
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Type 2 diabetes is characterized by insulin resistance leading to dysregulation of glucose control and chronic hyperglycemia. This leads to several co-morbidities and complications, some of which are associated with damage to blood vessels as a result of elevated blood glucose levels.
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The disease is progressive: patients’ standard of living deteriorate over time and the symptoms worsen, meaning more complex treatment regimens are required over time.
The complexity of the treatment means there is a high diversity of marketed products. In recent years new drug types have been great commercial successes and reached blockbuster status.
This alongside the financial cost of type 2 diabetes to healthcare providers has led to significant investment in R&D on therapeutics in this area.
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- Requirement for new types of therapeutics to add to already complex treatment algorithms for severe T2DM
- What are the most important etiological risk factors and pathophysiological processes implicated in T2DM?
- What is the current treatment algorithm?
- How effective are current therapies for these indications, and how does this impact prognosis? What are the side effects associated with these treatments?
- The T2DM pipeline is dominated by G-protein-coupled receptors (GPCRs) and protein kinases
- Which molecule types and molecular targets are most prominent in the T2DM pipeline?
- Which first-in-class targets are most promising?
- How does the level of first-in-class innovation change within different target classes?
- How does first-in-class target diversity differ by stage of development and molecular target class?
- The deals landscape is active and dominated by products that target GPCRS and protein kinases
- Which molecular types/molecular target groups attract the highest deal values?
- How has deal activity fluctuated over the past decade?
- Which first-in-class pipeline products have no prior involvement in licensing or co-development deals?
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Reasons to access
- Appreciate the current clinical and commercial landscapes by considering disease pathogenesis, etiology, epidemiology, symptoms, and diagnosis and treatment options.
- Identify leading products and key unmet needs within the market.
- Recognize innovative pipeline trends by analyzing therapies by stage of development, molecule type and molecular target.
- Assess the therapeutic potential of first-in-class targets. Using proprietary matrix assessments, first-in-class targets in the pipeline have been assessed and ranked according to clinical potential.
Individual matrix assessments are provided for targets identified in the pipeline for T2DM. Promising early-stage first-in-class targets are reviewed in greater detail.
- Consider first-in-class pipeline products with no prior involvement in licensing and co-development deals that may represent potential investment opportunities.
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Some Points from Table of Content:
1 Table of Contents 2
1.1 List of Tables 4
1.2 List of Figures 4
2 Executive Summary 6
2.1 Competitive Market Landscape Driven by Rising Prevalence 6
2.2 Large and Diverse Pipeline Dominated by Products Acting on G Protein Coupled Receptors (GPCR) and Protein Kinases 6
2.3 Strong Opportunities for Investment in First-in-Class Products 6
3 The Case for Innovation 7
3.1 Growing Opportunities for Biologic Products 7
3.2 Diversification of Molecular Targets 8
3.3 Innovative First-in-Class Product Developments Remain Attractive 8
3.4 Regulatory and Reimbursement Policy Shifts Favor First-in-Class Innovation 9
3.5 Sustained Innovation in Type 2 Diabetes Mellitus 9
4 Clinical and Commercial Landscape 10
4.1 Overview of Type 2 Diabetes Mellitus 10
4.2 Disease Classification 10
4.2.1 Type 1 Diabetes Mellitus 10
4.2.2 Type 2 Diabetes Mellitus 11
4.2.3 Type 3 Diabetes Mellitus 11
4.2.4 LADA 11
4.2.5 MODY 11
4.2.6 Gestational 11
4.2.7 Pancreatic diabetes 11
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