Transitional cell carcinoma (TCC) occur in the different parts of urinary tract, which include kidney, bladder, or urethra.
Transitional cell Carcinoma is one of the most the most common the malignant tumor which line the inner layers of urinary tract. There exists many sites which are affected by TCC is the trigone i.e a tissue, that covers the base of the urinary bladder, between the openings of the ureters and urethra., or neck of the bladder, where the bladder joins the urethra.
Bladder cancer also known as Transitional cell carcinoma (TCC) is the fifth most common cancer in men, and its half in women. Transitional cell carcinoma (TCC) occurs at any age also in children, TCC is very rare the under the age of 50 years and usually presents in old age population.
More than 90% of transitional cell cancer are diagnosed at the bladder lining called as urothelium and are known as urothelial carcinomas, There are few other types of bladder cancers, which are squamous cell carcinomas and adenocarcinomas, which are geographical and are found rare in Australia. The Urological Society reports around 75% of bladder cancers are superficial and the treatment is comparatively simple, but in there are cases constituting 25% of cases the cancer which invade the bladder wall, and further complete removal of the bladder is essential.
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Over the period of time, the cancer may grow outside the urinary bladder and then to other internal surrounding areas. It may then spread to nearby lymph nodes, the lungs, or the liver or to the other parts of the body in a very short span of time.
There are different types of Transitional cell cancer based on how far the cancer cells are invaded into the wall:
- Non-invasive– Cancer if in the inner layer of the cell i.e., in transitional epithelium
- Invasive Cancer– Cancer in the deeper layers bladder wall next to transitional epithelium
- Papillary Carcinomas– Grow in slender, finger-like projections from the inner surface of the bladder toward the hollow center of the bladder
- Flat carcinomas– Grow in slender, finger-like projections from the inner surface of the bladder but do not grow towards the hollow center of the bladder
Other Types of cancer that starts form the bladder, but are less common:
- Squamous cell carcinoma: Only about 2% to 4% of bladder cancers are squamous cell carcinomas
- Adenocarcinoma: Only about 1% of bladder cancers are adenocarcinomas
- Small cell carcinoma: Less than 1% of bladder cancers are small-cell carcinomas
The tests that you have to diagnose TCC may include
- Urine tests
- Intravenous pyelogram (IVP)
- Retrograde pyelography
- CT scan
- MRI scan
- Chest X-ray
Global market for Transitional Cell Cancer Treatment Market is segmented on the basis of treatment, by end user and region:
Segmentation by Surgery
- Transurethral resection of bladder tumor
- Urinary diversion
Segmentation by Chemotherapy
- Intravesical chemotherapy
- Systemic chemotherapy
- Doxorubicin Hydrochloride
- Radiation Therapy
Segmentation by End User
- Cancer Research Institutes
- Multispecialty Clinics
- Ambulatory Surgical Centers
Market revenue drivers for the transitional cell cancer therapeutics market include increase in environmental pollution levels coupled with high rates of cigarette smoking. The latter factor is said to contribute approximately 50% of the disease burden for the disease under consideration.
Other revenue drivers include focused and collaborative research on urothelial and badder cancer from leading agencies. Increase in innovations in targeted therapies in order to reduce toxicity at cellular levels could also help increase treatment effectiveness and thus fueling revenues of drug makers.
Barriers for the market include detection of the disease at late stages, lack of access to high valued drugs in low income countries where smoking rates are high, and lack of availability of sufficient curative treatment options currently. Process related barriers include long approval duration for drugs, and narrowed route to market opportunities apart from others.
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Some of the major market players in Transitional Cell Cancer Treatment (TCCT) Market globally include AstraZeneca, Roche, Bristol-Myers Squibb, Pfizer, Exelixis, Eisai, Merck & Co, Eli Lilly and Co and Celgene Corporation.
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